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| Monitoring Latent Virus Reactivation and Shedding in Astronauts |
| DSO 493 |
| In-Cabin |
| Overview |
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This DSO will attempt to determine the frequency of induced reactivation of latent viruses, latent virus shedding, and clinical disease after exposure to the physical, physiological, and psychological stressors associated with space flight. Saliva samples are collected from the participating astronauts every other day from six to four months before the launch to establish shedding profiles. Ten milliliters of blood and urine are collected during a routine preflight physical. During the flight, saliva specimens are collected once each day and stored for postflight evaluation. |
| History/Background |
| Space flight-induced alterations of immune response will become increasingly important on long-duration missions, including the possible reactivation and shedding (dissemination) of latent viruses. One type of latent virus is herpes simplex type 1 (HSV-1), which infects 70-80 percent of all adults. Its manifestation is classically associated with cold sores, pharyngitis, and tonsillitis, and it is usually acquired through contact with the saliva, skin, or mucous membranes of an infected individual. However, many recurrences are asymptomatic, resulting in shedding of the virus. |
Editorial/Technical Comments: ShuttlePresskit
